ヤマト　マサユキ   Yamato Masayuki   大和　雅之    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Cell sheet transplantation prevents inflammatory adhesions: A new treatment for adhesive otitis media.
掲載誌名	正式名：Regenerative Therapy ISSNコード：2352-3204
掲載区分	国外
巻・号・頁	18,pp.457-463
著者・共著者	YAMAMOTO Kazuhisa†*, MORINO Tsunetaro, KASAI Yoshiyuki, KIKUCHI Shun, KOMORI Manabu, YAMATO Masayuki, KOJIMA Hiromi
発行年月	2021/12
概要	Introduction:We developed a new treatment method that combines tympanoplasty with transplantation of autologous cultured nasal mucosal epithelial cell sheets to regenerate the mucosa of patients with adhesive otitis media, which has been difficult to treat effectively. We verified whether this procedure could be performed safely and measured its therapeutic efficacy.Methods:Autologous nasal mucosal epithelial cell sheets were manufactured at a good manufacturing practice-compliant cell processing facility using autologous nasal mucosal tissue. We performed tympanoplasty and transplanted the cell sheets into the middle ear cavity in six patients with adhesive otitis media.Results:The manufactured autologous cultured epithelial cell sheets met the predetermined quality standards and were successfully transplanted safely in all cases. Computed tomography findings after cell sheet transplantation showed that aeration in the tympanic cavity was maintained or restored in five of the six patients (83.3%). Four of the six (66.7%) patients had postoperative air-bone gap within 20 dB, which is considered a postoperative success in tympanoplasty for chronic middle ear disease.Conclusions:The results of this clinical study suggest that tympanoplasty with cell sheet transplantation can be used to treat adhesive otitis media by reliably preventing re-adhesion of the tympanic membrane.
DOI	10.1016/j.reth.2021.10.001
PMID	34805451