ナガシマ　ヨウジ   Nagashima Youji   長嶋　洋治    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Recurrent spindle cell carcinoma of the lung successfully treated by chemoimmunotherapy.
掲載誌名	正式名：Respirology case reports 略　 称：Respirol Case Rep ISSNコード：20513380/20513380
掲載区分	国外
巻・号・頁	9(6),pp.e00757
著者・共著者	AKABA Tomohiro†, SHIOTA Yuno, ONIZAWA Fumi, ISAKA Tamami, NAGASHIMA Yoji, TAGAYA Etsuko
発行年月	2021/06
概要	There is limited evidence for the treatment of sarcomatoid lung carcinoma, especially spindle cell carcinoma (SpCC) because of the rarity of disease. Although the efficacy of combination of chemotherapy and immunotherapy (i.e. chemoimmunotherapy) for non-small cell lung cancer (NSCLC) is well recognized, the effect for SpCC is not fully elucidated. A 72-year-old woman underwent surgical resection for the treatment of stage IIIA SpCC. Recurrence occurred three months after surgery, and then she received combination of carboplatin, paclitaxel, bevacizumab, and atezolizumab. A clinically favourable response was achieved by four cycles of chemoimmunotherapy and sequential maintenance therapy with bevacizumab and atezolizumab. The prognosis of advanced SpCC is generally poor, but chemoimmunotherapy can be a good therapeutic option for the first-line treatment of SpCC.
DOI	10.1002/rcr2.757
PMID	33976886