ムラガキ　ヨシヒロ   Muragaki Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differential Effects of a Left Frontal Glioma on the Cortical Thickness and Complexity of Both Hemispheres.
掲載誌名	正式名：Cerebral cortex communications 略　 称：Cereb Cortex Commun ISSNコード：26327376/26327376
掲載区分	国外
巻・号・頁	1(1),pp.tgaa027
著者・共著者	KINNO Ryuta†, MURAGAKI Yoshihiro, MARUYAMA Takashi, TAMURA Manabu, TANAKA Kyohei, ONO Kenjiro, SAKAI Kuniyoshi L*
担当区分	2nd著者
発行年月	2020/07/24
概要	Glioma is a type of brain tumor that infiltrates and compresses the brain as it grows. Focal gliomas affect functional connectivity both in the local region of the lesion and the global network of the brain. Any anatomical changes associated with a glioma should thus be clarified. We examined the cortical structures of 15 patients with a glioma in the left lateral frontal cortex and compared them with those of 15 healthy controls by surface-based morphometry. Two regional parameters were measured with 3D-MRI: the cortical thickness (CT) and cortical fractal dimension (FD). The FD serves as an index of the topological complexity of a local cortical surface. Our comparative analyses of these parameters revealed that the left frontal gliomas had global effects on the cortical structures of both hemispheres. The structural changes in the right hemisphere were mainly characterized by a decrease in CT and mild concomitant decrease in FD, whereas those in the peripheral regions of the glioma (left hemisphere) were mainly characterized by a decrease in FD with relative preservation of CT. These differences were found irrespective of tumor volume, location, or grade. These results elucidate the structural effects of gliomas, which extend to the distant contralateral regions.
DOI	10.1093/texcom/tgaa027
PMID	34296101