ムラガキ　ヨシヒロ   Muragaki Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Task-Induced Functional Connectivity of the Syntax-Related Networks for Patients with a Cortical Glioma.
掲載誌名	正式名：Cerebral cortex communications 略　 称：Cereb Cortex Commun ISSNコード：26327376/26327376
掲載区分	国外
巻・号・頁	1(1),pp.tgaa061
著者・共著者	TANAKA, Kyohei†, KINNO Ryuta, MURAGAKI Yoshihiro, MARUYAMA Takashi, SAKAI Kuniyoshi L*
発行年月	2020/07/24
概要	Analysis of the functional connectivity has enabled understanding of the cortical networks. In the present study, we used a picture-sentence matching task to introduce syntactically harder conditions, and clarified 3 major points. First, patients with a glioma in the lateral premotor cortex/inferior frontal gyrus or in other cortical regions showed much weaker activations than controls, especially in the left inferior frontal gyrus. Moreover, the error rates under the harder conditions were much higher for these patients. Secondly, syntactic loads induced selective connectivity with enhancement and suppression, consistently for both patients and controls. More specifically, the local connectivity was enhanced among the 3 syntax-related networks within the left frontal cortex, while the global connectivity of both dorsal and ventral pathways was suppressed. In addition, the exact reproducibility of r-values across the control and patient groups was remarkable, since under easier conditions alone, connectivity patterns for the patients were completely unmatched with those for the controls. Thirdly, we found an additional syntax-related network, further confirming the intergroup similarity of task-induced functional connectivity. These results indicate that functional connectivity of agrammatic patients is mostly preserved regardless of a glioma, and that the connectivity can change dynamically and systematically according to syntactic loads.
DOI	10.1093/texcom/tgaa061
PMID	34296124