アキヤマ　ヨシカツ   Akiyama Yoshikatsu   秋山　義勝    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Synthesis of Temperature-Responsive Polymers Containing Piperidine Carboxamide and N,N-diethylcarbamoly Piperidine Moiety via RAFT Polymerization.
掲載誌名	正式名：Macromolecular rapid communications 略　 称：Macromol Rapid Commun ISSNコード：15213927/10221336
掲載区分	国内
巻・号・頁	42(15),pp.e2100208
著者・共著者	AKIYAMA Yoshikatsu
担当区分	筆頭著者,責任著者
発行年月	2021/06/18
概要	In this study, poly(N-acryloyl-nipecotamide) (PNANAm), poly(N-acryloyl-isonipecotamide) (PNAiNAm), and poly(N-acryloyl-N,N-diethylnipecotamide) (PNADNAm) are synthesized as novel temperature-responsive polymers using reversible addition-fragmentation chain-transfer polymerization. Aqueous solutions of these three polymers are examined via temperature-dependent optical transmittance measurements. The PNANAm sample with a hydrophilic terminal group shows an upper critical solution temperature (UCST) in phosphate-buffered saline (PBS) when its molecular weight (Mn ) is 7600 or higher, whereas PNANAm (Mn < 7600) is soluble. The UCST is influenced by molecular weight and the polymer concentration. In contrast, PNANAm sample with nonionic terminal group shows UCST, when Mn is below 7600, suggesting that the terminal nonionic group possibly increases UCST of PNANAm. The urea addition experiment suggests that the driving force for expression of UCST of PNANAm is the formation of inter-and intramolecular hydrogen bonds among the polymer chains. PNAiNAm is soluble in PBS but exhibits an UCST in an appropriate concentration of ammonium sulfate. In contrast, PNADNAm exhibits a lower critical solution temperature. Comparing the chemical structure of these polymers and their phase transition behaviors suggests that the carboxamide group position in the piperidine ring could determine the UCST expression. These results could help design temperature-responsive polymers with a desired the cloud point temperature.
DOI	10.1002/marc.202100208
PMID	34145666