オオツキ　ミチオ   Ootsuki Michio   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Debulking surgery for functional pleural dissemination of parathyroid carcinoma-case report
掲載誌名	正式名：Journal of cardiothoracic surgery 略　 称：J Cardiothorac Surg ISSNコード：17498090/17498090
掲載区分	国外
巻・号・頁	16(1),pp.86
著者・共著者	Kawagishi Sachi, Funaki Soichiro, Ose Naoko, Kimura Kenji, Mukai Kosuke, Otsuki Michio, Shintani Yasushi
発行年月	2021/04
概要	BACKGROUND:A rare cause of primary hyperparathyroidism (PHPT) is a parathyroid carcinoma. Hypercalcemia with an elevated parathyroid hormone (PTH) level seen in recurrent and metastasis disease cases is often refractory to medical therapy, thus surgical resection is recommended when possible. We performed debulking surgery for pleural dissemination of parathyroid cancer for improvement of symptoms in a patient with hypercalcemia.CASE PRESENTATION:A 30-year-old male with hypercalcemia was diagnosed with parathyroid cancer. Following surgery, intact PTH level elevation and hypercalcemia progression due to recurrent disease were noted. An active status of functional left pleural dissemination was revealed in 99mTc-methoxyisobutylisonitrile and somatostatin receptor scintigraphy results, but not in the area of pulmonary metastasis, and debulking surgery was performed. Thereafter, the PTH level was decreased temporarily and activities of daily living improved.CONCLUSION:Aggressive resection of metastatic disease in patients with a parathyroid carcinoma is taken into consideration to control hypercalcemia.
DOI	10.1186/s13019-021-01477-z
PMID	33858470