オオツキ　ミチオ   Ootsuki Michio   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Biological characteristics of growth hormone-producing pituitary adenomas are different according to responsiveness to thyrotropin-releasing hormone
掲載誌名	正式名：The Journal of clinical endocrinology and metabolism 略　 称：J Clin Endocrinol Metab ISSNコード：19457197 (Electronic)0021972X (Linking)
掲載区分	国外
巻・号・頁	97(8),pp.2741-2747
著者・共著者	Arita, H. Kinoshita, M. Oshino, S. Kitamura, T. Otsuki, M. Kasayama, S. Shimokawa, T. Shimomura, I. Yoshimine, T. Saitoh, Y.
発行年月	2012
概要	OBJECTIVE: The paradoxical response of GH to TRH in patients with acromegaly has been previously reported. However, few reports have focused on tumor characteristics reflected by this response. This study aimed to clarify the relationship between TRH-induced GH responsiveness and other tumor characteristics. METHODS: Patients with acromegaly who underwent initial surgery between 2000 and 2012 were divided into TRH-responder and nonresponder groups. Clinical features were compared between the two groups with respect to tumor size, Knosp grade, endocrinological profiles, and histopathological findings revealed by cytokeratin staining. Tumor size was quantitatively evaluated with volumetry. Cytokeratin staining patterns were categorized into three groups: sparsely granulated type, densely granulated type, and intermediate type. RESULTS: Sixty-two patients were included in the study. TRH responders (n = 45) showed significantly smaller tumor size than nonresponders (n = 17) (2.78 +/- 4.71 vs. 7.56 +/- 9.00 ml, P<0.005). In addition, TRH responders showed significantly higher preoperative basal GH per volume ratio than nonresponders (10.1 +/- 8.4 vs. 7.72 +/- 11.85 ng/ml(2), P<0.05). Logarithmic regression modeling showed significant correlation between TRH responsiveness and tumor volume (r = -0.341; P<0.01). The difference between cytokeratin staining patterns was also significant: sparsely granulated-type adenomas were found in only 13% of TRH responders but in 64% of nonresponders (P<0.0005). TRH responders showed higher GH suppression rates in the octreotide test compared with nonresponders (86 vs. 68%, P<0.01). CONCLUSION: The present data suggest that the responsiveness of serum GH level to TRH reflects significant tumor biological characteristics.
DOI	10.1210/jc.2012-1125
文献番号	22569237