オオツキ　ミチオ   Ootsuki Michio   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway
掲載誌名	正式名：PloS one 略　 称：PLoS One ISSNコード：19326203 (Electronic)19326203 (Linking)
掲載区分	国外
巻・号・頁	8(2),pp.e56071
著者・共著者	Hu, D. Fukuhara, A. Miyata, Y. Yokoyama, C. Otsuki, M. Kihara, S. Shimomura, I.
発行年月	2013
概要	Adiponectin is exclusively expressed in adipose tissues and exhibits protective effects against cardiovascular and metabolic diseases. It enhances AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the liver and skeletal muscles, however, its signaling pathways in macrophages remain to be elucidated. Here, we show that adiponectin upregulated the expression of vascular endothelial growth factor (VEGF)-C, and induced phosphorylation of extracellular signal-regulated kinase (ERK) in macrophages. Inhibition of Syk abrogated adiponectin-induced VEGF-C expression and ERK phosphorylation. Furthermore, inhibition of ERK blocked the induction of VEGF-C gene. Inhibition of Syk, but not that of ERK, abrogated adiponectin-induced expression of cyclooxygenase (COX)-2, tissue inhibitor of metalloproteinase (TIMP)-1, and interleukin (IL)-6. These results indicate that adiponectin regulates VEGF-C expression via Syk-ERK pathway in macrophages.
DOI	10.1371/journal.pone.0056071
文献番号	23424645