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オオツキ ミチオ
Ootsuki Michio
大月 道夫 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Incompatibility between fasting and postprandial plasma glucose in patients with Cushing's syndrome |
| 掲載誌名 | 正式名：Endocrine Journal 略 称：Endocr J ISSNコード：09188959 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 63(11),pp.1017-1023 |
| 著者・共著者 | Otsuki, M. Kitamura, T. Tamada, D. Tabuchi, Y. Mukai, K. Morita, S. Kasayama, S. Shimomura, I. Koga, M. |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2016 |
| 概要 | It is shown that glucocorticoids have discordant effects on plasma glucose concentration through their effects on hepatic glycogen deposition, gluconeogenesis and peripheral insulin resistance. Cushing's syndrome caused by cortisol overproduction is frequently accompanied with diabetes mellitus, but fasting plasma glucose (FPG) and post-glucose load plasma glucose levels are not examined in patients with Cushing's syndrome. The aim of this study was to investigate FPG, HbA1c and oral glucose tolerance test (OGTT) 2-h PG and their relationship in patients with Cushing's syndrome, in comparison with control subjects. Sixteen patients with Cushing's syndrome (ACTH-dependent 31%, ACTH-independent 69% and diabetes mellitus 50%) and 64 controls (32 patients with type 2 diabetes mellitus and 32 non-diabetic subjects matched for age, sex and BMI) were enrolled in this study. HbA1c and FPG in the patients with Cushing's syndrome were not different from the controls, whereas the FPG/HbA1c ratio was significantly lower in the patients with Cushing's syndrome than the controls. OGTT 2-h PG was significantly higher in the non-diabetic patients with Cushing's syndrome than the non-diabetic controls, while HbA1c was not different between both groups and FPG was significantly lower in the patients with Cushing's syndrome than the controls. HOMA-beta but not HOMA-R was significantly higher in the patients with Cushing's syndrome than the controls. In conclusion, FPG was rather lower in the patients with Cushing's syndrome than the controls. Postprandial PG or post-glucose loaded PG, but not FPG, is useful to evaluate the abnormality of glucose metabolism in patients with Cushing's syndrome. |
| DOI | 10.1507/endocrj.EJ15-0748 |
| 文献番号 | 27498594 |