オオツキ　ミチオ   OOTSUKI Michio   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient
掲載誌名	正式名：Internal Medicine 略　 称：Intern Med ISSNコード：09182918
掲載区分	国内
巻・号・頁	56(9),pp.1071-1077
著者・共著者	D. Hayashi R Yamaoka, M. Nishizawa, H. Fukuda, S. Fujishima, Y. Kimura, T. Kozawa, J. Kita, S. Matsuoka, T. A. Otsuki, M. Imagawa, A. Ichida, K. Taniguchi, A. Maeda, N. Funahashi, T. Shimomura, I.
発行年月	2017
概要	A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. In addition, multiple gouty tophi with bone erosion and destruction might have been caused by hypoadiponectinemia and the elevation of the patient's pro-inflammatory cytokine (IL-1beta) level with the accumulation of visceral fat. In this case, bone and Ga-67 scintigraphy were useful for detecting the location and magnitude of gouty tophi.
DOI	10.2169/internalmedicine.56.7923
文献番号	28458315