オオツキ　ミチオ   OOTSUKI Michio   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced obesity
掲載誌名	正式名：The Journal of endocrinology 略　 称：J Endocrinol ISSNコード：00220795
掲載区分	国外
巻・号・頁	239(1),pp.63-71
著者・共著者	Hayakawa, T. Minemura, T. Onodera, T. Shin, J. Okuno, Y. Fukuhara, A. Otsuki, M. Shimomura, I.
発行年月	2018
概要	Active glucocorticoid levels are elevated in the adipose tissue of obesity due tothe enzyme 11beta-hydroxysteroid dehydrogenase type 1. Glucocorticoids can bind and activate both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and pharmacological blockades of MR prevents high-fat diet-induced obesity and glucose intolerance. To determine the significance of MR in adipocytes, we generated adipocyte-specific MR knockout mice (AdipoMR-KO) and fed them high-fat/high-sucrose diet. We found that adipocyte-specific deletion of MR did not affect the body weight, fat weight, glucose tolerance, or insulin sensitivity. While liver weight was slightly reduced in AdipoMR-KO, there were no significant differences in the mRNA expression levels of genes associated with lipogenesis, lipolysis, adipocytokines, and oxidative stress in adipose tissues between the control and AdipoMR-KO mice. The results indicated that MR in mature adipocytes plays a minor role in the regulation of insulin resistance and inflammation in high-fat/high-sucrose diet-induced obese mice.
DOI	10.1530/joe-18-0026
文献番号	30049823