オオツキ　ミチオ   Ootsuki Michio   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Association of abdominal obesity with crossing capillaries in the finger nailfold in type 2 diabetes mellitus
掲載誌名	正式名：Diabetology international. 略　 称：Diabetol Int ISSNコード：21901678/21901686
掲載区分	国内
巻・号・頁	12(3),pp.260-267
著者・共著者	Shikama, M. Sonoda, N. Morimoto, A. Suga, S. Tajima, T. Kozawa, J. Maeda, N. Otsuki, M. Matsuoka, T. A. Shimomura, I. Ohno, Y.
発行年月	2021
概要	Aim: Increased crossing of finger nailfold capillaries could be a novel visual marker of early microvascular damage among type 2 diabetes mellitus patients. Although abdominal obesity is an important driver of early microvascular damage, its association with an increase in the percentage of crossing capillaries remains uncertain. We investigated the association between abdominal obesity and an increase in the percentage of crossing capillaries in the finger nailfold in patients with type 2 diabetes mellitus. Methods: This cross-sectional study enrolled 123 type 2 diabetes mellitus patients (age 40-75 years) who visited the outpatient diabetic clinic at Osaka University Hospital between May and October 2019. Abdominal obesity was defined as a waist circumference>/= 90 cm in women and>/= 85 cm in men. Capillary morphology was assessed by nailfold capillaroscopy based on the simple capillaroscopic definitions of the European League Against Rheumatism Study Group. The association between abdominal obesity and a high percentage of crossing capillaries in the finger nailfold (defined as the highest tertile of crossing capillaries) was analyzed using multivariable logistic regression. Results: After adjusting for age, sex, smoking status, regular exercise, duration of diabetes, glycated hemoglobin, hypertension, and dyslipidemia, abdominal obesity was significantly associated with a high percentage of crossing capillaries (multivariable-adjusted odds ratios [95% confidence interval]= 2.70 [1.05-6.90], p = 0.038). Conclusions: Abdominal obesity may play an important role in the increase in the percentage of crossing capillaries in the finger nailfold in patients with type 2 diabetes mellitus.
DOI	10.1007/s13340-020-00480-4
文献番号	34150434