オオツキ　ミチオ   OOTSUKI Michio
  大月　道夫
   所属   医学部 医学科（東京女子医科大学病院）
   職種   教授・基幹分野長
Article types Original article
Language English
Peer review Peer reviewed
Title Circulating vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic NIDDM patients
Journal Formal name：Diabetes
Abbreviation：Diabetes
ISSN code：00121797 (Print)00121797 (Linking)
Domestic / ForeginForegin
Volume, Issue, Page 46(12),pp.2096-2101
Author and coauthor Otsuki, M. Hashimoto, K. Morimoto, Y. Kishimoto, T. Kasayama, S.
Authorship Lead author
Publication date 1997
Summary Vascular cell adhesion molecule-1 (VCAM-1) has been shown to be highly expressed in atherosclerotic lesions. Although the soluble form of VCAM-1 (sVCAM-1) is detected in human sera, the relation between the degree of atherosclerosis and serum sVCAM-1 level has not been defined. In the present study, sVCAM-1 concentrations were measured in sera from 101 Japanese NIDDM patients. The mean +/- SD serum sVCAM-1 concentration in 26 patients with symptomatic atherosclerotic vascular diseases (789 +/-187 ng/ml) was higher than that in 75 patients without the disease (664 +/- 175 ng/ml). Among the 101 NIDDM patients, 56 had atherosclerotic change of the carotid arteries, based on the evaluation by high-resolution B-mode ultrasonography. Their sVCAM-1 level was 759 +/- 201 ng/ml, higher than that in 45 patients without any detectable atherosclerosis of the carotid arteries (619 +/- 130 ng/ml). In addition, there was a positive correlation between sVCAM-1 concentration and thickness of the intimal plus medial complex (IMT) of the carotid arteries in the NIDDM patients (r = 0.41, P<0.0001). Multivariate regression analysis revealed significant predictors of mean IMT value to be sVCAM-1 concentration (F = 62.88, P = 0.0001) and age (F = 9.59, P = 0.0026). By contrast, sVCAM-1 concentration was not increased in nondiabetic patients with atherosclerotic change of the carotid arteries (668 +/- 191 ng/ml; n = 36) compared with those without the atherosclerotic change (632 +/- 177 ng/ml; n = 28), and there was no correlation between sVCAM-1 level and IMT of the carotid arteries in the nondiabetic subjects. These results indicate that circulating sVCAM-1 may be a marker of atherosclerotic lesions in NIDDM patients with symptomatic and asymptomatic atherosclerosis.
DOI 10.2337/diab.46.12.2096.
Document No. 9392502