オオツキ　ミチオ   Ootsuki Michio   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Adipose tissue macrophages induce PPARgamma-high FOXP3(+) regulatory T cells
掲載誌名	正式名：Scientific Reports ISSNコード：20452322
掲載区分	国外
巻・号・頁	5,pp.16801
著者・共著者	Onodera, T. Fukuhara, A. Jang, M. H. Shin, J. Aoi, K. Kikuta, J. Otsuki, M. Ishii, M. Shimomura, I.
発行年月	2015
概要	Numerous regulatory T cells (Tregs) are present in adipose tissues compared with other lymphoid or non-lymphoid tissues. Adipose Tregs regulate inflammatory state and insulin sensitivity. However, the mechanism that maintains Tregs in adipose tissue remains unclear. Here, we revealed the contribution of adipose tissue macrophages (ATMs) to the induction and proliferation of adipose Tregs. ATMs isolated from mice under steady state conditions induced Tregs with high expression of PPARgamma compared with splenic dendritic cells in vitro. Furthermore, ATMs from obese mice prompted the differentiation of PPARgamma low Tregs. Adoptive transfer of ATMs induced differentiation and proliferation of Tregs, whereas depletion of ATMs by clodronate-liposome resulted in reduction of adipose Tregs, in vivo. Deficiency of anti-inflammatory adipocytokine, Adipoq, resulted in small proportions of ATMs and adipose Tregs without alteration of other immune cells in vivo. Therefore, these data suggest that the abundance of Tregs in adipose tissue could be partly attributed to the ability of ATMs to induce PPARgamma-expressing Tregs.
DOI	10.1038/srep16801
文献番号	26582486