オオツキ　ミチオ   Ootsuki Michio   大月　道夫    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Suppression Failure of Cortisol Secretion by Dexamethasone May Occur in Glucagon-like Peptide-1 Receptor Agonist-treated Patients with Diabetic Autonomic Neuropathy
掲載誌名	正式名：Internal Medicine 略　 称：Intern Med ISSNコード：09182918
掲載区分	国内
巻・号・頁	58(7),pp.949-953
著者・共著者	Nagai, Y. Mukai, K. Otsuki, M. Kimura, T. Kozawa, J. Nishizawa, H. Maeda, N. Matsuoka, T. A. Iwahashi, H. Imagawa, A. Shimomura, I.
担当区分	責任著者
発行年月	2018
概要	Two diabetic women (case 1, 75 years old; case 2, 49 years old) being treated with GLP-1 receptor agonists (GLP-1 RAs) showed no suppression of cortisol secretion on a dexamethasone suppression test (DST). However, its secretion was suppressed after switching from GLP-1 RAs to insulin. We also checked the cortisol secretion by a DST in five consecutive inpatients (case 3-7) being treated with GLP-1 RAs. The coefficients of R-R interval variation at rest and during deep breathing were lower in the two false-positive cases (case 1 and 2) than in the five true-negative cases (case 3-6). GLP-1 RAs can be switched to insulin in order to eliminate the slow absorption effect of dexamethasone by GLP-1 RAs if a DST is planned in diabetic patients receiving GLP-1 RAs.
DOI	10.2169/internalmedicine.1585-18
文献番号	30568127