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オカモト ユウコ
OKAMOTO Yuuko
岡本 祐子 所属 医学部 医学科（東京女子医科大学病院） 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Complement and its environmental determinants in the progression of human rheumatoid arthritis. |
| 掲載誌名 | 正式名：Molecular immunology 略 称：Mol Immunol ISSNコード：18729142/01615890 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 112,pp.256-265 |
| 著者・共著者 | Bemis Elizabeth A, Norris Jill M, Seifert Jennifer, Frazer-Abel Ashley, Okamoto Yuko, Feser Marie L, Demoruelle M Kristen, Deane Kevin D, Banda Nirmal K, Holers V Michael |
| 発行年月 | 2019/08 |
| 概要 | Rheumatoid arthritis (RA) is a complex autoimmune disease with an etiology that is not yet well understood, disproportionally affects women and also varies in incidence and prevalence by population. The presence of anti-citrullinated protein antibodies (ACPA) is a highly specific biomarker for the diagnosis of clinically apparent RA. ACPA are also present in the serum for an average of 3-5 years prior to the onset of RA during an asymptomatic period characterized by mucosal inflammation and local ACPA production at these sites. We hypothesized that systemic complement activation products might be generated during the pre-clinical initiation of RA and/or provide a second hit that promotes subsequent arthritis development in the joints. In addition, we evaluated which demographic and genetic features and environmental exposures could influence the complement activation process. We analyzed plasma from healthy subjects, subjects at-risk for the development of RA based on serum ACPA positivity in absence of inflammatory arthritis (IA), and ACPA positive RA subjects by Multiplex Assay and ELISA for eighteen complement system components, factors and activation products belonging to the classical, lectin and alternative pathways. By using regression models, associations between complement proteins and various demographic, genetic, and environmental factors previously found to be associated with RA, including sex, smoking, shared epitope, and oral contraceptive use, were examined. We found no evidence of systemic complement activation in ACPA positive subjects without IA, but in contrast found evidence of systemic involvement of the both classical and alternative pathways during the stage of the disease where classified RA is present, (i.e. during joint inflammation and damage). With regard to the demographic, genetic, and environmental variables, females who reported current or past oral contraceptive use and subjects with current tobacco exposure demonstrated alterations |
| DOI | 10.1016/j.molimm.2019.05.012 |
| PMID | 31207549 |