イイヅカ　ユズル   Iidzuka Yuzuru   飯塚　讓    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue.
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：20452322/20452322
掲載区分	国外
巻・号・頁	6,pp.21481
著者・共著者	Hirako Satoshi, Wada Nobuhiro, Kageyama Haruaki, Takenoya Fumiko, Izumida Yoshihiko, Kim Hyounju, Iizuka Yuzuru, Matsumoto Akiyo, Okabe Mai, Kimura Ai, Suzuki Mamiko, Yamanaka Satoru, Shioda Seiji
発行年月	2016/02
概要	Galanin-like peptide (GALP) is a neuropeptide involved in the regulation of feeding behavior and energy metabolism in mammals. While a weight loss effect of GALP has been reported, its effects on lipid metabolism have not been investigated. The aim of this study was to determine if GALP regulates lipid metabolism in liver and adipose tissue via an action on the sympathetic nervous system. The respiratory exchange ratio of mice administered GALP intracerebroventricularly was lower than that of saline-treated animals, and fatty acid oxidation-related gene mRNA levels were increased in the liver. Even though the respiratory exchange ratio was reduced by GALP, this change was not significant when mice were treated with the sympatholytic drug, guanethidine. Lipolysis-related gene mRNA levels were increased in the adipose tissue of GALP-treated mice compared with saline-treated animals. These results show that GALP stimulates fatty acid β-oxidation in liver and lipolysis in adipose tissue, and suggest that the anti-obesity effect of GALP may be due to anorexigenic actions and improvement of lipid metabolism in peripheral tissues via the sympathetic nervous system.
DOI	10.1038/srep21481
PMID	26892462