オオシマ　シヨウコ   Ooshima Shiyouko   大嶋　祥子    所属   医学部 医学科（東京女子医科大学病院）    職種   嘱託医師
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Successful Rituximab Treatment in Thrombotic Thrombocytopenic Purpura Patients Complicated by Other Autoimmune Disorders: Two Case Reports.
掲載誌名	正式名：Internal medicine (Tokyo, Japan) 略　 称：Intern Med ISSNコード：13497235/09182918
掲載区分	国外
巻・号・頁	60(17),pp.2859-2862
著者・共著者	Watanabe Aya†, Shiseki Masayuki, Oishi Megumi, Kobayashi Maya, Oshima Shoko, Osanai Satoko, Ryuzaki Michiko, Izuka Yuki, Tanaka Norina, Ishiyama Midori, Shinohara Akihito, Kazama Hiroshi, Hagiwara Shotaro, Yoshinaga Kentaro, Tanaka Junji
発行年月	2021/09
概要	We herein report two cases of thrombotic thrombocytopenic purpura (TTP) complicated by other autoimmune disorders, autoimmune hepatitis and immune thrombocytopenia, respectively. In both cases, corticosteroids were continuously administered for the treatment of preceding autoimmune disorders. However, a sufficient objective response for TTP was not obtained by plasma exchange and corticosteroid treatment. Once a week rituximab (375 mg/m2) treatment for 4 times was initiated within 2 weeks from the diagnosis. Both patients achieved a sufficient response, and have never had any recurrence as of the last follow-up dates. The early introduction of rituximab could be an effective treatment option in TTP patients complicated with other autoimmune disorders.
DOI	10.2169/internalmedicine.6387-20
PMID	33775998