ニシノ　タカヨシ   Nishino Takayoshi   西野　隆義    所属   医学部 医学科（附属八千代医療センター）    職種   教授
論文種別	症例報告
言語種別	英語
査読の有無	査読なし
表題	Hepatocellular carcinoma in young morbid obese patients with non-alcoholic fatty liver disease.
掲載誌名	正式名：Clinical journal of gastroenterology 略　 称：Clin J Gastroenterol ISSNコード：18657265/18657265
掲載区分	国内
巻・号・頁	13(6),pp.1289-1296
著者・共著者	TOBARI Maki, HASHIMOTO Etsuko, TANIAI Makiko, NISHINO Takayoshi, TOKUSHIGE Katsutoshi, Nishino Takayoshi
発行年月	2020/12
概要	We report the two youngest cases of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) among our 119 NAFLD-HCC patients. A 36-year-old man was referred to our hospital due to a 5 cm in diameter liver tumor with elevation of α-fetoprotein and des-γ-carboxy prothrombin found at his annual health check. He had no symptoms other than 20 kg weight loss. He has been morbidly obese since he was a child. At the time of the diagnosis of NAFLD-HCC, blood chemistry showed FIB4-index 0.52, α-fetoprotein 11.1 ng/mL and des-γ-carboxy prothrombin 361 mAU/mL. He underwent curative operation. The non-cancerous lesion showed steatohepatitis with mild fibrosis. A 41-year-old man was diagnosed as having a huge liver tumor (15 cm in diameter) during medical examination for 10 kg weight loss. He had no clinical symptoms except weight loss. He has been morbidly obese since childhood. NAFLD was diagnosed at age 20. At the time of the HCC diagnosis, blood chemistry showed FIB4-index 1.42, α-fetoprotein 1974 ng/mL, and des-γ-carboxy prothrombin 82,602 mAU/mL. He underwent curative operation. We have to be aware that HCC can develop in young NAFLD patients without advanced fibrosis. Concerning tumor markers, elevation of des-γ-carboxy prothrombin was more sensitive than α-fetoprotein.
DOI	10.1007/s12328-020-01215-3
PMID	32880022