ニシノ　タカヨシ   Nishino Takayoshi   西野　隆義    所属   医学部 医学科（附属八千代医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Guidance for diagnosing autoimmune pancreatitis with biopsy tissues.
掲載誌名	正式名：Pathology international 略　 称：Pathol Int ISSNコード：14401827/13205463
掲載区分	国外
巻・号・頁	70(10),pp.699-711
著者・共著者	Notohara Kenji, Kamisawa Terumi, Fukushima Noriyoshi, Furukawa Toru, Tajiri Takuma, Yamaguchi Hiroshi, Aishima Shinichi, Fukumura Yuki, Hirabayashi Kenichi, Iwasaki Eisuke, Kanno Atsushi, Kasashima Satomi, Kawashima Atsuhiro, Kojima Motohiro, Kubota Kensuke, Kuraishi Yasuhiro, Mitsuhashi Tomoko, Naito Yoshiki, Naitoh Itaru, Nakase Hiroshi, Nishino Takayoshi, Ohike Nobuyuki, Sakagami Junichi, Shimizu Kyoko, Shiokawa Masahiro, Uehara Takeshi, Ikeura Tsukasa, Kawa Shigeyuki, Okazaki Kazuichi
発行年月	2020/10
概要	The biopsy-based diagnosis of autoimmune pancreatitis (AIP) is difficult but is becoming imperative for pathologists due to the increased amount of endoscopic ultrasound-guided biopsy tissue. To cope with this challenge, we propose guidance for the biopsy diagnosis of type 1 AIP. This guidance is for pathologists and comprises three main parts. The first part includes basic issues on tissue acquisition, staining, and final diagnosis, and is intended for gastroenterologists as well. The second part is a practical guide for diagnosing type 1 AIP based on the AIP clinical diagnostic criteria 2018. Inconsistent histological findings, tips for evaluating IgG4 immunostaining and key histological features including the ductal lesion and others are explained. Storiform fibrosis and obliterative phlebitis are diagnostic hallmarks but are sometimes equivocal. Storiform fibrosis is defined as spindle-shaped cells, inflammatory cells and fine collagen fibers forming a flowing arrangement. Obliterative phlebitis is defined as fibrous venous obliteration with inflammatory cells. Examples of each are provided. The third part describes the differentiation of AIP from pancreatic ductal adenocarcinoma (PDAC), focusing on histological features of acinar-ductal metaplasia in AIP, which is an important mimicker of PDAC. This guidance will help standardize pathology reports of pancreatic biopsies for diagnosing type 1 AIP.
DOI	10.1111/pin.12994
PMID	32767550