イズモ　ワタル   Izumo Wataru   出雲　渉    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	A Comparison of the Pathological Types of Undifferentiated Carcinoma of the Pancreas.
掲載誌名	正式名：Pancreas 略　 称：Pancreas ISSNコード：15364828/08853177
掲載区分	国外
巻・号・頁	49(2),pp.230-235
著者・共著者	SHIIHARA Masahiro, HIGUCHI Ryota, IZUMO Wataru, FURUKAWA Toru, YAMAMOTO Masakazu
発行年月	2020/02
概要	OBJECTIVES:This study aimed to identify the detailed clinicopathological features of undifferentiated carcinoma of the pancreas (UCP).METHODS:We investigated clinical, imaging features and the prognoses of 261 patients; 8 were our patients, and the remainder were identified by searching English-language articles in PubMed.RESULTS:We classified patients with UCP into 3 types based on pathological findings: osteoclast-like giant cell-associated carcinoma, pleomorphic cell carcinoma (PLC), and spindle cell carcinoma. There were no remarkable differences in clinical, radiological features between these 3 types. However, PLCs were significantly more likely to be unresectable than were the other 2 types (P < 0.001). Patients with osteoclast-like giant cell-associated carcinoma achieved the best overall survival (OS) rates (P < 0.001), whereas those with spindle cell carcinoma had significantly longer OS rates than did those with PLC (P = 0.004). These OS patterns were maintained when considering only those patients who underwent resection. Patients with PLC had both lower curative resection and high lymph node metastasis rates (P = 0.029, P = 0.023). Patients who underwent resection had more favorable prognoses than did those who did not.CONCLUSIONS:Surgery is the first choice for resectable UCP. Pleomorphic cell carcinoma is particularly malignant; postoperative treatment should be introduced immediately.
DOI	10.1097/MPA.0000000000001483
PMID	32011534