オオキ　タケシ   Ooki Takeshi   大木　岳志    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	総説
言語種別	英語
査読の有無	査読なし
表題	Esophageal regenerative therapy using cell sheet technology.
掲載誌名	正式名：Regenerative therapy 略　 称：Regen Ther ISSNコード：23523204/23523204
掲載区分	国外
巻・号・頁	13,pp.8-17
著者・共著者	OHKI Takeshi, YAMAMOTO Masakazu
担当区分	筆頭著者
発行年月	2020/03
概要	We have been conducting research on esophageal regenerative therapy using cell sheet technology. In particular, in the endoscopic field, we have pushed forward clinical research on endoscopic transplantation of cultured autologous oral mucosal epithelial cell sheets to esophageal ulcer after endoscopic submucosal dissection (ESD). We started research in this direction using animal models in 2004 and performed clinical research in 2012 in collaboration with Nagasaki University and Karolinska Institute. Although in full-circumferential cases it was difficult to prevent esophageal stricture after ESD, there were no complications and stricture could be suppressed. The cell sheet technology is still in its infancy. However, we are convinced that it has a high potential for application in various areas of gastrointestinal science. In this review, we focus on the pre-clinical and clinical trial results obtained and on the theoretical aspects of (1) stricture prevention, (2) esophageal tissue engineering research, and (3) endoscopic transplantation, and review the esophageal regenerative therapy by cell sheet technology.
DOI	10.1016/j.reth.2020.04.009
PMID	33490318