タキザワ　コウタロウ   Takizawa Koutarou   瀧澤　光太郎    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Distribution of mRNA for GPR143, a receptor of 3,4-L-dihydroxyphenylalanine, and of immunoreactivities for nicotinic acetylcholine receptors in the nigrostriatal and mesolimbic regions.
掲載誌名	正式名：Neuroscience research 略　 称：Neurosci Res ISSNコード：18728111/01680102
掲載区分	国外
巻・号・頁	170,pp.370-375
著者・共著者	Kasahara Yuka, Masukawa Daiki, Nakamura Yoshie, Murata Koshi, Hashimoto Tatsuo, Takizawa Kohtaro, Koga Motokazu, Nakamura Fumio, Fukazawa Yugo, Funakoshi Kengo, Goshima Yoshio
発行年月	2020/09/05
概要	Nicotine exerts its reinforcing actions by activating nicotinic acetylcholine receptors (nAChRs), but the detailed mechanisms remain unclear. Nicotine releases 3, 4-dihydroxyphenylalanine (DOPA), a neurotransmitter candidate in the central nervous system. Here, we investigated the distribution of GPR143, a receptor of DOPA, and nAChR subunits in the nigrostriatal and mesolimbic regions. We found GPR143 mRNA-positive cells in the striatum and nucleus accumbens. Some of them were surrounded by tyrosine hydroxylase (TH)-immunoreactive fibers. There were some GPR143 mRNA-positive cells coexpressing TH, and nAChR subunit α4 or α7 in the substantia nigra and ventral tegmental area. These findings suggest that DOPA-GPR143 signaling may be involved in the nicotine action in the nigrostriatal and mesolimbic dopaminergic systems.
DOI	10.1016/j.neures.2020.08.003
PMID	32896531