カワマタ　タカカズ   Kawamata Takakazu   川俣　貴一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effect of Epirubicin Against Glioma Initiating Cells
掲載誌名	正式名：Tokyo Women's Medical University Journal ISSNコード：24326186
掲載区分	国内
出版社	東京女子医科大学学会
巻・号・頁	4,pp.69-76
著者・共著者	NAKAJIMA Atsushi† , SAMPETREAN Oltea , KOIKE Naoyoshi, NITTA Masayuki, SAYA Saya, KAWAMATA Takakazu, MURAGAKI Yoshihiro
発行年月	2020/11/21
概要	Background: Glioblastoma is a highly aggressive primary malignant brain tumor. New treatments, especially ones that can eradicate subpopulations with stem-cell-like properties, are currently being explored. In vitro, epirubicin has demonstrated toxicity towards such populations. However, epirubicin fails to readily cross the blood-brain barrier. Furthermore, its efficacy against stem-like tumor cells growing within the neural tissue has not been fully addressed. Polymeric micelles are an advanced system developed to enhance drug delivery into tumors. Methods: We have investigated the effect of epirubicin micelles against murine glioma initiating cells (GICs) in vitro and ex vivo. Results: In vitro, epirubicin micelles inhibited the sphere growth of GICs in a dose-dependent manner. Furthermore, they also inhibited the growth of GIC-based tumors in ex vivo cultured brain slices from the tumor-bearing mice. This effect was inversely proportional to the tumor size at the beginning of the treatment. Conclusions: Our results suggest that epirubicin micelles are effective against murine glioma cells with stem cell properties and their use should be initiated at an early stage.
DOI	10.24488/twmuj.2020002