オオキ　タケシ   Ooki Takeshi   大木　岳志    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Evaluation of human keratinocyte sheets transplanted onto porcine excised esophagus after submucosal dissection in an ex vivo model
掲載誌名	正式名：Regenerative Therapy ISSNコード：2352-3204
掲載区分	国外
巻・号・頁	15,pp.323-331
著者・共著者	KAWAI Yosuke†, TAKAGI Ryo, OHKI Takeshi, YAMAMOTO Masakazu*, YAMATO Masayuki*
発行年月	2020/12/10
概要	Background The utility of endoscopic transplantation of epithelial cell sheets to ulcer sites after endoscopic submucosal dissection (ESD) has been shown to prevent scar stenosis after ESD of early esophageal cancer. Previously, our group reported use of an endoscopic transplantation device fabricated with a 3-dimensional printer. Cell sheets are transplanted to the esophageal wound site with the following procedure: first, a cell sheet harvested from temperature-responsive culture dishes is placed on the device's deflated balloon surface and transported to the wound site with endoscopic forceps; second, by applying pressure from inflating the balloon locally at the wound site, the cell sheet is successfully transferred and adhered to the wound tissue; third, the balloon is deflated, and the device is removed. By repeating the procedure, several cell sheets can be safely transplanted to a wider ESD area. Nonetheless, possible damage to cell sheets using this procedure has not yet been assessed.
DOI	10.1016/j.reth.2020.11.004
PMID	33426235