シミズ　ユウコ   Shimizu Yuuko   清水　優子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs) after left orbital contusion.
掲載誌名	正式名：Epileptic disorders : international epilepsy journal with videotape 略　 称：Epileptic Disord ISSNコード：12949361/12949361
掲載区分	国外
巻・号・頁	14(4),pp.422-5
著者・共著者	Takeda Takahiro, Osawa Mikio, Toi Sono, Mizuno Satoko, Shimizu Yuko, Uchiyama Shinichiro
発行年月	2012/12
概要	We report a patient who presented with adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs), a month after head trauma. The PLEDs predominantly involving the left frontal contacts became more frequent at the onset of adversive seizures during EEG. Brain MRI demonstrated a contusion scar in the left orbital cortex with reduced diffusion, not only around this orbital lesion but also in the ipsilateral anteromedial thalamus. Single photon emission computed tomography revealed focal cerebral hyperperfusion in the left medial orbitofrontal region, basal ganglia, and thalamus. The abnormal metabolism involving the thalamus and striatum could be associated with the ipsilateral orbital contusion and might have been caused by cortical-subcortical, trans-synaptic hyperactivity. Further studies are warranted to determine the role of subcortical structures in the generation of PLEDs and adversive seizures. [Published with video sequences].
DOI	10.1684/epd.2012.0537
PMID	23247965