シミズ　ユウコ   Shimizu Yuuko   清水　優子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica.
掲載誌名	正式名：Journal of Neuroimmunology 略　 称：J Neuroimmunol ISSNコード：18728421/01655728
掲載区分	国外
巻・号・頁	263(1-2),pp.148-151
著者・共著者	Shimizu Yuko†*, Ota Kohei, Ikeguchi Ryotaro, Kubo Sachiko, Kabasawa Chiaki, Uchiyama Shinichiro
担当区分	筆頭著者,責任著者
発行年月	2013/10
概要	Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple sclerosis (MS) and neuromyelitis optica (NMO) patients to investigate its value as a potential biomarker of disease activity. In NMO patients, plasma OPN levels were significantly higher than those in healthy individuals, being equivalent to those in MS patients. In both NMO and MS patients, OPN levels were significantly higher during relapse compared with remission. There was also a significant positive correlation between Expanded Disability Status Scale of Kurzke scores and plasma OPN levels in both NMO and MS patients, and plasma OPN levels were significantly higher in patients with secondary progressive MS compared with those with relapsing-remitting MS. Diagnostic sensitivity and specificity of plasma OPN for MS and NMO during the relapse phase were 100% and 50%, respectively (cut-off point: 31.3ng/ml). Thus, elevated plasma OPN levels could be a potential biomarker for not only MS but also NMO. These are the first results to suggest that plasma OPN in NMO patients may be a useful marker, playing an important role in inflammation, disease activity, and disease progression, as well as MS.
DOI	10.1016/j.jneuroim.2013.07.005
PMID	23910387