コガ　ヨウコ   KOGA Youko   古賀　陽子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	HIV-associated Burkitt lymphoma in a Japanese patient with early submandibular swelling.
掲載誌名	正式名：BMC research notes 略　 称：BMC Res Notes ISSNコード：17560500/17560500
掲載区分	国外
巻・号・頁	6,pp.557
著者・共著者	Komatsu Noriko, Kawase-Koga Yoko, Mori Yoshiyuki, Kamikubo Yasuhiko, Kurokawa Mineo, Takato Tsuyoshi
発行年月	2013/12
概要	BACKGROUND:Patients infected with the human immunodeficiency virus (HIV) are at risk of developing malignancies and have an increased susceptibility to infection. HIV-associated Burkitt lymphoma (BL) is relatively rare in developed countries, but remains prevalent in developing counties and is sometimes compounded by the fact that patients may be unaware that they are HIV-positive.CASE PRESENTATION:A 37-year-old Japanese man was referred to our department for diagnosis and management of submandibular swelling. He was unaware that he was HIV-positive at the initial visit. Here, we describe our diagnostic approach, in which we used hematological and immunological investigations, biopsy, fluorescence-activated cell sorting and fluorescence in situ hybridization to confirm the diagnosis of HIV-associated BL. The patient has no risk factors for HIV infection, and the source of infection remains unclear.CONCLUSIONS:In this case, submandibular swelling was the first clinical sign of pathology and the patient's HIV-positive status only became evident later. It is highly likely that BL was triggered by HIV infection.
DOI	10.1186/1756-0500-6-557
PMID	24370065