コガ　ヨウコ   KOGA Youko   古賀　陽子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system.
掲載誌名	正式名：Developmental dynamics : an official publication of the American Association of Anatomists 略　 称：Dev Dyn ISSNコード：10970177/10588388
掲載区分	国外
巻・号・頁	238(11),pp.2800-12
著者・共著者	Kawase-Koga Yoko, Otaegi Gaizka, Sun Tao
発行年月	2009/11
概要	MicroRNAs, processed by the RNAase III enzyme Dicer, are approximately 22 nucleotide endogenous noncoding small RNAs. The function of Dicer in the mouse central nervous system (CNS) development is not well understood. Here, we show that specifically deleting Dicer expression in the CNS and in the cerebral cortex using two Cre lines results in reduced progenitor numbers, abnormal neuronal differentiation, and thinner cortical wall. Incomplete Dicer deletion during early embryonic stages contributes to normal development of early-born neurons in the cortex and motor neurons in the spinal cord. However, at late embryonic stages when Dicer is completely ablated in the CNS, the migration of late-born neurons in the cortex and oligodendrocyte precursor expansion and differentiation in the spinal cord are greatly affected. Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development.
DOI	10.1002/dvdy.22109
PMID	19806666