ウツギサワ　タイジユ   UTSUGISAWA Taijiyu   槍澤　大樹    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Role for E2F in DNA damage-induced entry of cells into S phase.
掲載誌名	正式名：Cancer research 略　 称：Cancer Res ISSNコード：00085472/00085472
掲載区分	国外
巻・号・頁	57(17),pp.3640-3643
著者・共著者	Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kato T, Yuan Z M
発行年月	1997/09
概要	Mammalian cells respond to ionizing radiation (IR) with transient cell cycle arrest and induction of apoptosis. Here we show that IR increases the expression of the E2F-1 transcription factor and the entry of cells into S phase. E2F-1 transactivation function is inhibited by cyclin A-kinase to ensure orderly progression through S phase. However, in contrast to proliferating cells, IR treatment results in down-regulation of cyclin A-kinase. Expression of a dominant negative form of the E2F heterodimeric partner DP-1 confirmed the involvement of E2F in IR-induced S-phase entry. These findings also support opposing signals involving the induction of E2F and the down-regulation of cyclin A-kinase in the IR response.
PMID	9288762