シガ　ツヨシ   Shiga Tsuyoshi   志賀　剛    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Low-dose systemic phosphodiesterase III inhibitor pimobendan combined with prostacyclin therapy in a patient with severe primary pulmonary hypertension.
掲載誌名	正式名：Cardiovascular drugs and therapy 略　 称：Cardiovasc Drugs Ther ISSNコード：09203206/09203206
掲載区分	国外
巻・号・頁	17(4),pp.375-9
著者・共著者	Watanabe Eri, Shiga Tsuyoshi, Matsuda Naoki, Kajimoto Katsuya, Naganuma Miyoko, Kawai Akihiko, Kasanuki Hiroshi
発行年月	2003/07
概要	Pimobendan, an oral inotropic drug with phosphodiesterase III-inhibitory activity, induces cAMP-dependent relaxation of vascular smooth muscle in the pulmonary artery, as well as in the systemic cardiovascular system. We report here a patient with severe primary pulmonary hypertension (PPH), who had developed right heart failure (New York Heart Association functional class IV) despite uptitrated intravenous epoprostenol, and who was treated with extremely low-dose (0.625-1.25 mg daily) pimobendan as an adjunct to prostacyclin therapy. The combination therapy of low-dose pimobendan, prostacyclin, intravenous epoprostenol and oral beraprost has been continued for over 2 years without occurrence of fatal arrhythmia, and her six-minute walk test has exceeded 400 m. We suggest that low-dose pimobendan may enhance the hemodynamic effect of prostacyclin in severe PPH.
DOI	10.1023/a:1027328614686
PMID	14696637