ストウ　チカコ   Sutou Chikako   須藤　史子    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Efficacy and safety of prophylactic intracameral moxifloxacin injection in Japan.
掲載誌名	正式名：Journal of cataract and refractive surgery 略　 称：J Cataract Refract Surg ISSNコード：18734502/08863350
巻・号・頁	39(11),pp.1702-1706
著者・共著者	Matsuura Kazuki,† Miyoshi Teruyuki, Suto Chikako, Akura Junsuke, Inoue Yoshitsugu
発行年月	2013/11
概要	PURPOSE:To report endophthalmitis rates after cataract surgery and the incidence of complications after intracameral moxifloxacin injection.SETTING:Nineteen clinics in Japanese institutions.DESIGN:Retrospective survey cohort study.METHODS:The number of surgeries and endophthalmitis cases in the past 4 years before and after the introduction of intracameral moxifloxacin was evaluated. The survey was performed by mail or interview in February 2013.RESULTS:All institutions used total-replacement administration rather than small-volume injection. At 3 institutions, 50 to 100 μg/mL moxifloxacin; at 9 institutions, 100 to 300 μg/mL moxifloxacin; and at 7 institutions, 500 μg/mL moxifloxacin was administered. The highest concentration (500 μg/mL) was administered in 14,124 cases. Endophthalmitis cases occurred 1 month or sooner postoperatively in 8 of 15,958 cases (ie, 1 in 1955) without intracameral moxifloxacin administration and in 3 of 18,794 cases (ie, 1 in 6265) with intracameral moxifloxacin administration.CONCLUSIONS:Intracameral moxifloxacin (50 to 500 μg/mL) administration decreased the risk for endophthalmitis by 3-fold. In more than 18,000 cases, moxifloxacin administration of 500 μg/mL or less did not result in severe complications, such as toxic anterior segment syndrome or corneal endothelial cell loss.
DOI	10.1016/j.jcrs.2013.05.036
PMID	24054967