モリナガ　アキノリ   Morinaga Akinori   森永　明倫    所属   医学部 医学科（附属東洋医学研究所）    職種   助教
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	One-year intranasal application of growth hormone releasing peptide-2 improves body weight and hypoglycemia in a severely emaciated anorexia nervosa patient.
掲載誌名	正式名：Journal of cachexia, sarcopenia and muscle 略　 称：J Cachexia Sarcopenia Muscle ISSNコード：21905991/21905991
掲載区分	国外
巻・号・頁	6(3),pp.237-41
著者・共著者	Haruta Izumi, Fuku Yuki, Kinoshita Kazuhisa, Yoneda Koichi, Morinaga Akinori, Amitani Marie, Amitani Haruka, Asakawa Akihiro, Sugawara Hideki, Takeda Yasuo, Bowers Cyril Y, Inui Akio
発行年月	2015/09
概要	BACKGROUND:In Japan, growth hormone releasing peptide-2 (GHRP-2) is clinically used as a diagnostic agent for growth hormone secretion deficiency, but the therapeutic application of GHRP-2 has not been studied in anorexia nervosa. GHRP-2 reportedly exhibits agonistic action for ghrelin receptor and increases food intake.METHODS:We administered GHRP-2 to a patient with a 20-year history of anorexia nervosa to determine whether GHRP-2 treatment increases food intake and body weight. GHRP-2 was administered before every meal by an intranasal approach for 1 year.RESULTS:Although the patient reported a decreased fear of eating and decreased desire to be thin by our previous treatment, she was unable to increase food intake or body weight because of digestive tract dysfunction. Vomiting after meals caused by delayed gastric emptying and incurable constipation were prolonged, and sub-ileus and hypoglycemia were observed. GHRP-2 increased the feeling of hunger and food intake, decreased early satiety and improved hypoglycemia. The patient's body weight gradually increased by 6.7 kg (from 21.1 kg to 27.8 kg) in 14 months after starting GHRP-2 administration. The fatigability and muscle strength improved, and the physical and mental activities were also increased. No obvious side effects were observed after long-term intranasal administration of GHRP-2.CONCLUSIONS:Patients with a long-term history of eating disorder occasionally recover from the psychological problems such as fear for obesity but remain emaciated. We believe that ghrelin agonists such as GHRP-2 may be promising agents for the effective treatments of severe anorexia nervosa in a chronic condition.
DOI	10.1002/jcsm.12028
PMID	26401470