コジマ　ミツアキ   Kojima Mitsuaki   小島　光暁    所属   その他 その他    職種   嘱託医師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The role of mesenteric lymph exosomal lipid mediators following intestinal ischemia-reperfusion injury on activation of inflammation.
掲載誌名	正式名：The journal of trauma and acute care surgery 略　 称：J Trauma Acute Care Surg ISSNコード：21630763/21630755
掲載区分	国外
巻・号・頁	89(6),pp.1099
著者・共著者	Senda Atsushi, Morishita Koji, Kojima Mitsuaki, Doki Sanae, Taylor Beth, Yagi Masayuki, Watanabe Arisa, Kobayashi Tetsuyuki, Aiboshi Junichi, Coimbra Raul, Otomo Yasuhiro
担当区分	筆頭著者
発行年月	2020/07
概要	BACKGROUND:Intestinal ischemia caused by hemorrhagic shock is known to induce systemic inflammatory responses. Previous studies have shown that mesenteric lymph (ML) plays a crucial role in gut-mediated inflammation. Lipid mediators, such as lysophosphatidylcholines (LPCs) which contain polyunsaturated fatty acids (PUFAs), are present in the post-shock ML. Exosomes are also present in the ML and act as transcellular carriers of lipids; however, their role in post-shock systemic inflammation has not been revealed. Here, we aimed to identify changes in lipid mediators in ML exosomes after intestinal ischemia.
DOI	10.1097/TA.0000000000002897
PMID	32769950