コジマ　ミツアキ   Kojima Mitsuaki   小島　光暁    所属   その他 その他    職種   嘱託医師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction.
掲載誌名	正式名：The journal of trauma and acute care surgery 略　 称：J Trauma Acute Care Surg ISSNコード：21630763/21630755
掲載区分	国外
巻・号・頁	84(2),pp.257-264
国際共著	国際共著
著者・共著者	Kojima Mitsuaki, Costantini Todd W, Eliceiri Brian P, Chan Theresa W, Baird Andrew, Coimbra Raul
担当区分	筆頭著者
発行年月	2018/02
概要	BACKGROUND:Exosomes are extracellular vesicles that act as endogenous mediators of the immune response. We have previously shown that exosomes released into mesenteric lymph (ML) following trauma (T)/hemorrhagic shock (HS) induce proinflammatory cytokine production in macrophages and are involved in the pathogenesis of postshock acute lung injury. However, the cellular origin of ML exosomes and their role in the posttrauma immune response remains unclear. We hypothesized that exosomes released from damaged-intestinal epithelial cells contribute to posttrauma immune dysfunction by altering the function of dendritic cells (DCs), key regulators of the adaptive immunity.
DOI	10.1097/TA.0000000000001748
PMID	29194317