ニワ　ユキコ   NIWA Yukiko   丹羽　由紀子    所属   医学部 医学科（附属八千代医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effect of landiolol hydrochloride on tachyarrhythmia after esophagectomy.
掲載誌名	正式名：Hepato-gastroenterology 略　 称：Hepatogastroenterology ISSNコード：01726390/01726390
掲載区分	国外
巻・号・頁	61(134),pp.1546-51
著者・共著者	Niwa Yukiko, Koike Masahiko, Iwata Naoki, Kobayashi Daisuke, Tanaka Chie, Fujii Tsutomu, Nakayama Goro, Sugimoto Hiroyuki, Fujiwara Michitaka, Kodera Yasuhiro
発行年月	2014/09
概要	BACKGROUND/AIMS:The objective of this study was to evaluate the efficacy and safety of landiolol hydrochloride, a newly developed ultra-short-acting β1-selective blocker, for postoperative tachyarrhythmia after esophagectomy.METHODOLOGY:In total 231 patients underwent transthoracic esophagectomy at the Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine from 2007 to 2012. Twenty-four patients who were treated with either landiolol hydrochloride (n = 11) or conventional agents (combination of calcium channel blocker and digitalis preparation; control group, n = 13) for postoperative tachyarrhythmia after transthoracic esophagectomy were retrospectively analyzed. Tachyarrhythmia was defined as a heart rate of >120 bpm or atrial fibrillation. Hemodynamic changes, conversion rates, and adverse events were evaluated.RESULTS:The reduction in the heart rate at 1 h after medication was seen significantly more frequent in the landiolol group than in the control group. The time to conversion to sinus rhythm was also significantly shorter in the landiolol group. There were no significant differences between the two groups in blood pressure either before or after the medication. One patient in the landiolol group showed hypotension and bradycardia, without serious consequences.CONCLUSIONS:Landiolol hydrochloride can be effectively and safely used in patients who develop tachyarrhythmia after esophagectomy.
PMID	25436340