サノ　ケンタロウ   Sano Kentarou   佐野　賢太郎    所属   医学部 医学科（附属八千代医療センター）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prevalence and characteristics of human parechovirus and enterovirus infection in febrile infants.
掲載誌名	正式名：Pediatrics international : official journal of the Japan Pediatric Society 略　 称：Pediatr Int ISSNコード：1442200X/13288067
掲載区分	国内
巻・号・頁	60(2),pp.142-147
著者・共著者	Sano Kentaro, Hamada Hiromichi, Hirose Shoko, Sugiura Kenta, Harada Satoko, Koizumi Mai, Hara Mayumi, Nishijima Haruna, Taira Masakatsu, Ogura Atsushi, Ogawa Tomoko, Takanashi Jun-Ichi
発行年月	2018/02
概要	BACKGROUND:Human parechovirus (HPeV) and human non-polio enterovirus (EV) are important causes of fever without source (FWS) in young infants. Their prevalence and clinical characteristics are largely unknown in Asian countries. This study was conducted to elucidate the epidemiology and clinical characteristics of HPeV and EV infection in febrile young infants in Japan.METHODS:During February 2010-August 2015, we obtained 53 stool, 44 throat swab, and 20 cerebrospinal fluid samples from 56 infants (<3 months) with FWS at a single hospital. To each sample, we applied reverse transcription-polymerase chain reaction for HPeV and EV. We compared the clinical characteristics of HPeV and EV patients.RESULTS:HPeV was detected in 11 and EV in 17 patients. HPeV was detected during July-September. HPeV patients, compared with EV patients, had lower age (32 vs 47 days; P = n.s.), higher prevalence of exclusive breast-feeding (81.8 vs 29.4%; P = 0.024), and lower prevalence of sick contacts (36.4 vs 88.2%; P = 0.010). More HPeV than EV patients met the systemic inflammatory response syndrome criteria (90.9 vs 52.9%; P = 0.049). In the HPeV group, leukopenia, thrombopenia, and elevated deviation enzyme were observed, although the prevalence of abnormal cerebrospinal fluid was significantly lower than in the EV group. HPeV patients had longer hospital stay (7 vs 5 days; P = 0.025).CONCLUSION:HPeV and EV are important causal viruses of FWS. Characteristic clinical pictures exist in these virus infections, but further research is needed to accumulate more cases to produce a comprehensive picture of these virus infections.
DOI	10.1111/ped.13467
PMID	29205679