カワジリ　スミヒロ   KAWAJIRI Sumihiro   河尻　澄宏    所属   医学部 医学科（附属東洋医学研究所）    職種   准教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Mechanisms of mitochondrial fission and fusion.
掲載誌名	正式名：Cold Spring Harbor perspectives in biology 略　 称：Cold Spring Harb Perspect Biol ISSNコード：19430264/19430264
掲載区分	国外
巻・号・頁	5(6),pp.a011072
著者・共著者	van der Bliek Alexander M, Shen Qinfang, Kawajiri Sumihiro
発行年月	2013/06
概要	Mitochondria continually change shape through the combined actions of fission, fusion, and movement along cytoskeletal tracks. The lengths of mitochondria and the degree to which they form closed networks are determined by the balance between fission and fusion rates. These rates are influenced by metabolic and pathogenic conditions inside mitochondria and by their cellular environment. Fission and fusion are important for growth, for mitochondrial redistribution, and for maintenance of a healthy mitochondrial network. In addition, mitochondrial fission and fusion play prominent roles in disease-related processes such as apoptosis and mitophagy. Three members of the Dynamin family are key components of the fission and fusion machineries. Their functions are controlled by different sets of adaptor proteins on the surface of mitochondria and by a range of regulatory processes. Here, we review what is known about these proteins and the processes that regulate their actions.
DOI	10.1101/cshperspect.a011072
PMID	23732471