カワジリ　スミヒロ   KAWAJIRI Sumihiro   河尻　澄宏    所属   医学部 医学科（附属東洋医学研究所）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.
掲載誌名	正式名：Neuroscience letters 略　 称：Neurosci Lett ISSNコード：18727972/03043940
掲載区分	国外
巻・号・頁	481(2),pp.88-91
著者・共著者	Kawajiri Sumihiro, Machida Yutaka, Saiki Shinji, Sato Shigeto, Hattori Nobutaka
担当区分	筆頭著者
発行年月	2010/09
概要	Zonisamide, originally known as an antiepileptic drug, has been approved in Japan as adjunctive therapy with levodopa for the treatment of Parkinson's disease (PD). Although zonisamide reduces neurotoxicity, the precise mechanism of this action is not known. Here, we show that zonisamide increases cell viability in SH-SY5Y cells via an anti-apoptotic effect and by upregulating levels of manganese superoxide dismutase (MnSOD). These results would give us novel evidences of PD treatment.
DOI	10.1016/j.neulet.2010.06.058
PMID	20600601