カワジリ　スミヒロ   KAWAJIRI Sumihiro   河尻　澄宏    所属   医学部 医学科（附属東洋医学研究所）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy.
掲載誌名	正式名：FEBS letters 略　 称：FEBS Lett ISSNコード：18733468/00145793
掲載区分	国外
巻・号・頁	584(6),pp.1073-9
著者・共著者	Kawajiri Sumihiro, Saiki Shinji, Sato Shigeto, Sato Fumiaki, Hatano Taku, Eguchi Hiroto, Hattori Nobutaka
発行年月	2010/03
概要	Mutations in PTEN-induced putative kinase 1 (PINK1) cause recessive form of Parkinson's disease (PD). PINK1 acts upstream of parkin, regulating mitochondrial integrity and functions. Here, we show that PINK1 in combination with parkin results in the perinuclear mitochondrial aggregation followed by their elimination. This elimination is reduced in cells expressing PINK1 mutants with wild-type parkin. Although wild-type PINK1 localizes in aggregated mitochondria, PINK1 mutants localization remains diffuse and mitochondrial elimination is not observed. This phenomenon is not observed in autophagy-deficient cells. These results suggest that mitophagy controlled by the PINK1/parkin pathway might be associated with PD pathogenesis.
DOI	10.1016/j.febslet.2010.02.016
PMID	20153330