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イシズ アヤコ
Ishizu Ayako
石津 綾子 所属 医学部 医学科 職種 教授・基幹分野長 |
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| 論文種別 | 総説 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Hematopoietic Stem Cell Metabolism during Development and Aging. |
| 掲載誌名 | 正式名：Developmental cell 略 称：Dev Cell ISSNコード：18781551/15345807 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 54(2),pp.239-255 |
| 著者・共著者 | Nakamura-Ishizu Ayako, Ito Keisuke, Suda Toshio |
| 発行年月 | 2020/07 |
| 概要 | Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism. |
| DOI | 10.1016/j.devcel.2020.06.029 |
| PMID | 32693057 |