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イシズ アヤコ
Ishizu Ayako
石津 綾子 所属 医学部 医学科 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential. |
| 掲載誌名 | 正式名：Haematologica 略 称：Haematologica ISSNコード：15928721/03906078 |
| 掲載区分 | 国外 |
| 巻・号・頁 | Jun 11(haematol.2019.241406),pp.000-000 |
| 著者・共著者 | O'Neill Aled, Chin Desmond, Tan Darren, Abdul Majeed A Qilah Banu Bte, Nakamura-Ishizu Ayako, Suda Toshio |
| 発行年月 | 2020/06 |
| 概要 | Thrombopoietin (THPO) has long been known to influence megakaryopoiesis and hematopoietic stem and progenitor cells (HSPCs), though the exact mechanisms through which it acts are unknown. Here we show that MPL expression correlates with megakaryopoietic potential of HSPCs and identify a population of quiescent progenitor cells that show limited dependence on THPO signalling. We show that THPO is primarily responsible for maintenance of hematopoietic cells with megakaryocytic (Mk) differentiation potential and their subsequent Mk differentiation and maturation. The loss of Mks in THPO knockout (KO) mouse models results in a reduction of the Mk derived chemokine platelet factor 4 (CXCL4/PF4) in the bone marrow and administration of recombinant CXCL4/PF4 rescues the loss of progenitor cell quiescence observed in these mice. CXCL4/PF4 treatment does not rescue reduced HSPC numbers suggesting that thrombopoietin directly maintains HSPC numbers. |
| DOI | 10.3324/haematol.2019.241406 |
| PMID | 32527954 |