ヤスカワ　クミ   Yasukawa Kumi   安川　久美    所属   医学部 医学科（附属八千代医療センター）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Vital Signs as Predictor Factors of Intravenous Immunoglobulin Resistance in Patients With Kawasaki Disease.
掲載誌名	正式名：Clinical pediatrics 略　 称：Clin Pediatr (Phila) ISSNコード：19382707/00099228
掲載区分	国外
巻・号・頁	57(10),pp.1148-1153
著者・共著者	Gámez-González Luisa Berenise, Hamada Hiromichi, Cisneros Castolo Martín, Honda Takafumi, Yasukawa Kumi, Takanashi Jun-Ichi
発行年月	2018/09
概要	Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) may significantly lower the frequency of coronary artery complications. However, some patients do not respond to initial therapy and are at higher risk of developing coronary artery lesion. A retrospective analysis of data from 419 KD patients was performed. The patients were divided into IVIG responders (n = 318) and IVIG nonresponders (n = 101). Multivariate logistic regression analysis revealed neutrophil percentage, albumin, aspartate aminotransferase, heart rate, and body temperature were independent predictors of IVIG resistance. We generated a predictive scoring system by assigning 1 point for the presence of these parameters (neutrophil >80%, albumin <3.4 g/dL, aspartate aminotransferase >100 IU/L, heart rate >146 bpm, and body temperature >38.8°C). This scoring system had a sensitivity of 76.2% and specificity of 64.8%, and a positive predictive value of 40.1% and a negative predictive value of 89.4%. Vital signs may be helpful to detect KD patients with IVIG resistance.
DOI	10.1177/0009922818759320
PMID	29486579