ホンダ　タカフミ   Honda Takafumi   本田　隆文    所属   医学部 医学科（附属八千代医療センター）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Clinically mild infantile encephalopathy associated with excitotoxicity.
掲載誌名	正式名：Journal of the neurological sciences 略　 称：J Neurol Sci ISSNコード：18785883/0022510X
掲載区分	国外
巻・号・頁	373,pp.138-141
著者・共著者	Hirai Nozomi, Yoshimaru Daisuke, Moriyama Yoko, Honda Takafumi, Yasukawa Kumi, Takanashi Jun-Ichi
発行年月	2017/02
概要	Acute infectious encephalopathy is very frequently observed in children in East Asia including Japan. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype in Japan; however, more than 40% of the patients remain unclassified into specific syndromes. To investigate the underlying pathomechanism in those with unclassified acute encephalopathy, we evaluated brain metabolism by MR spectroscopy. Among 20 patients with acute encephalopathy admitted to our hospital during January 2015 to May 2016, 12 could not be classified into specific syndromes. MR spectroscopy was performed in 8 of these 12 patients with unclassified encephalopathy. MR spectroscopy showed an increase of glutamine with a normal N-acetyl aspartate level on days 3 to 8 in three of the 8 patients, which had normalized by follow-up studies. The three patients clinically recovered completely. This study suggests that excitotoxicity may be the underlying pathomechanism in some patients with unclassified mild encephalopathy.
DOI	10.1016/j.jns.2016.12.043
PMID	28131171