クロダ　ハジメ   Kuroda Hajime   黒田　一    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Nuclear Morphometry of Lung Squamous Cell Carcinomas in Cytologic Study.
掲載誌名	正式名：Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 略　 称：Ann Thorac Cardiovasc Surg ISSNコード：21861005/13411098
掲載区分	国外
巻・号・頁	24(6),pp.303-307
著者・共著者	Nishihira Morimichi, Nakazato Yoshimasa, Tsuchida Shigeru, Kuroda Hajime, Imai Yasuo, Chida Masayuki
発行年月	2018/12
概要	BACKGROUND:The nuclei of most cancer cells in histopathologic preparations differ from normal nuclei and vary individually in size, shape, and chromatin pattern. Although the cytologic characteristics of squamous cell carcinoma (SCC) of the lung have been described, quantification of the cytologic features has not been established.METHODS:Cytologic investigations were performed on bronchial brushings or washings, or fine-needle aspirates. We analyzed the nuclear area (NA) of 50 tumor cells in 32 patients with SCC of the lung and 50 bronchial epithelial cells in 20 patients with no evidence of malignancy including inflammatory lesions.RESULTS:The NA of tumor cells (102.4 ± 26.2 μm2) was significantly larger than that of bronchial epithelial cells (64.1 ± 16.9 μm2) (P = 0.001). The receiver operating characteristic (ROC) curve analysis showed that an NA cutoff level of 86 μm2 had a sensitivity of 75% and specificity of 88% to detect malignant components.CONCLUSION:We conducted quantitative analyses of NA in SCC using cytologic specimen, NA was a useful parameter for evaluation of differential diagnosis between SCC and non-malignancies even in cytologic specimens.
DOI	10.5761/atcs.oa.18-00005
PMID	30089760