クロダ　ハジメ   Kuroda Hajime   黒田　一    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast.
掲載誌名	正式名：Virchows Archiv : an international journal of pathology 略　 称：Virchows Arch ISSNコード：09456317/09456317
掲載区分	国外
巻・号・頁	446(1),pp.10-4
著者・共著者	Kuroda Hajime†*, Tamaru Jun-ichi, Sakamoto Goi, Ohnisi Kiyoshi, Itoyama Shinji
担当区分	筆頭著者,責任著者
発行年月	2005/01
概要	Medullary carcinoma (MC) of the breast is characterized by large anaplastic cells and infiltration by benign lymphocytes. Patients with this pattern of breast carcinoma are considered to have a better prognosis than those with other histological subtypes. We reviewed cases of primary breast carcinoma that were surgically resected between 1990 and 2004. Of these, 13 cases of medullary carcinoma of the breast with lymphocyte infiltration were reported. Tests for CD3, CD4, CD8, CD20, CD56, TIA-1, and granzyme B were performed on paraffin sections. We found that the MC contained very few NK cells, as assessed by their reactivity with the CD56 antibodies. However, MC had a significantly greater percentage of CD3, CD8, TIA-1, and granzyme B lymphocytes infiltrating the stroma of the tumor. Furthermore, more CD8-positive than CD4-positive T-cell lymphocytes were present within the tumor cell nests in MC, as opposed to the proportion in usual ductal carcinoma. The infiltrating cytotoxic/suppressor T cells in MC represent host resistance against cancer, and the high grading of the T-cell infiltration could explain, in part, a key mechanism controlling the good prognosis for this type of tumor and solve the pathological paradox of MC.
DOI	10.1007/s00428-004-1143-9
PMID	15660281