ナカジマ　レイコ   Nakajima Reiko   中島　怜子    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Safety and Feasibility of PARP1/2 Imaging with 18F-PARPi in Patients with Head and Neck Cancer.
掲載誌名	正式名：Clinical cancer research : an official journal of the American Association for Cancer Research 略　 称：Clin Cancer Res ISSNコード：10780432/10780432
掲載区分	国外
巻・号・頁	26(13),pp.3110-3116
著者・共著者	Schöder Heiko, França Paula Demétrio De Souza, Nakajima Reiko, Burnazi Eva, Roberts Sheryl, Brand Christian, Grkovski Milan, Mauguen Audrey, Dunphy Mark P, Ghossein Ronald A, Lyashchenko Serge K, Lewis Jason S, O'Donoghue Joseph A, Ganly Ian, Patel Snehal G, Lee Nancy Y, Reiner Thomas
発行年月	2020/07
概要	PURPOSE:We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility of PET imaging with 18F-PARPi in patients with head and neck cancer.PATIENTS AND METHODS:Eleven patients with newly diagnosed or recurrent oral and oropharyngeal cancer were injected with 18F-PARPi (331 ± 42 MBq), and dynamic PET/CT imaging was performed between 0 and 25 minutes postinjection. Static PET/CT scans were obtained at 30, 60, and 120 minutes postinjection. Blood samples for tracer concentration and metabolite analysis were collected. Blood pressure, ECG, oxygen levels, clinical chemistry, and complete blood count were obtained before and after tracer administration.RESULTS:18F-PARPi was well-tolerated by all patients without any safety concerns. Of the 11 patients included in the analysis, 18F-PARPi had focal uptake in all primary lesions (n = 10, SUVmax = 2.8 ± 1.2) and all 18F-FDG-positive lymph nodes (n = 34). 18F-PARPi uptake was seen in 18F-FDG-negative lymph nodes of 3 patients (n = 6). Focal uptake of tracer in primary and metastatic lesions was corroborated by CT alone or in combination with 18F-FDG. The overall effective dose with 18F-PARPi PET was 3.9 mSv - 5.2 mSv, contrast was high [SUVmax(lesion)/SUVmax(trapezius muscle) = 4.5] and less variable than 18F-FDG when compared with the genioglossus muscle (1.3 vs. 6.0, P = 0.001).CONCLUSIONS:Imaging of head and neck cancer with 18F-PARPi is feasible and safe. 18F-PARPi detects primary and metastatic lesions, and retention in tumors is longer than in healthy tissues.
DOI	10.1158/1078-0432.CCR-19-3484
PMID	32245901