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クリバヤシ シゲヒコ
Kuribayashi Shigehiko
栗林 茂彦 所属 医学部 医学科（東京女子医科大学病院） 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Utility of sonography for evaluation of clinical T1 and T2 glottic carcinoma. |
| 掲載誌名 | 正式名：Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 略 称：J Ultrasound Med ISSNコード：15509613/02784297 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 28(11),pp.1429-1440 |
| 著者・共著者 | KURIBAHASHI Shigehiko, MIYASHITA Tsuguhiro, NAKAMIZO Munenaga, YAGI Toshiaki, KUMITA Shinichiro |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2009/11 |
| 概要 | OBJECTIVE:The aim of this study was to evaluate the prognostic impact of sonographically determined tumor features in relation to local control of clinical T1 and T2 glottic carcinoma treated by definitive radiation therapy.METHODS:Between 1999 and 2005, 72 patients with T1 and T2 glottic carcinoma were evaluated by percutaneous sonography in terms of tumor detectability, maximum tumor dimension, involvement of the anterior commissure, presence of supraglottic, subglottic, or paraglottic spread, and thyroid cartilage invasion. Factor analyses for local control included clinical features, sonographic findings, and treatment factors.RESULTS:Forty-one lesions (57%) were detected as hypoechoic masses on sonography. For detectable T2 tumors, sonographic and laryngoscopic findings were in agreement in all cases with respect to spread to anatomic subsites. The 3-year local control rate with radiation therapy alone was 82%. Univariate analysis of the sonographic characteristics revealed that the maximum tumor dimension and thyroid cartilage invasion predicted a loss of local control, whereas none of the clinical or treatment characteristics was significant. Multivariate analysis showed that thyroid cartilage invasion was an independent negative prognostic factor for local control.CONCLUSIONS:Sonography provides information about the likely outcome of radiation therapy for patients with clinical T2 glottic carcinoma, although its utility for T1 lesions is not proven. Thyroid cartilage invasion may be an independent negative predictor of the outcome. |
| DOI | 10.7863/jum.2009.28.11.1429 |
| PMID | 19854956 |