コバヤシ ヒロヒト
Kobayashi Hirohito
小林 博人 所属 医学部 医学科(附属足立医療センター) 職種 准教授 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Gamma/delta T cells provide innate immunity against renal cell carcinoma. |
掲載誌名 | 正式名:Cancer immunology, immunotherapy : CII 略 称:Cancer Immunol Immunother ISSNコード:03407004/03407004 |
掲載区分 | 国外 |
巻・号・頁 | 50(3),pp.115-124 |
著者・共著者 | Kobayashi H, Tanaka Y, Yagi J, Toma H, Uchiyama T |
担当区分 | 筆頭著者 |
発行年月 | 2001/05 |
概要 | Host immune function plays a certain role against the development of renal cell carcinomas (RCCs), but the mechanism is not entirely understood. Human gamma/delta (gamma/delta) T cells defend the body against infection. In this study, we clarify the role of gamma/delta T cells in the surveillance system against RCCs by analyzing the gamma/delta T cells in peripheral blood mononucleocytes (PBMs) and tumor infiltrating lymphocytes (TILs) from 41 patients with RCCs. The results showed that the number of gamma/delta T cells expressing V gamma 2 and V delta 2 in variable elements of TCR was elevated in the PBMs in 10 patients, but not in any of 32 healthy individuals. The proportion of patients with an elevated number of gamma/delta T cells (> 10%) increased with cancer stage. The level of the gamma/delta T cells decreased after surgery. The gamma/delta T cells in the TILs were more activated than those in the PBMs. Evaluation of the junctional diversity of TCR V gamma 2 and V delta 2 chains showed that the increased peripheral blood gamma/delta T cells were oligoclonal rather than polyclonal. Taken together, our findings suggest that gamma/delta T cells recognize certain RCC-related antigens and play a role in the surveillance system against RCCs. |
DOI | 10.1007/s002620100173 |
PMID | 11419178 |