ナカバヤシ　アキラ   Nakabayashi Akira   中林　章    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Current status of preimplantation genetic diagnosis in Japan.
掲載誌名	正式名：Bioinformation 略　 称：Bioinformation ISSNコード：09732063/09732063
掲載区分	国外
巻・号・頁	11(5),pp.254-60
著者・共著者	Sato Kenji, Sueoka Kou, Iino Kotaro, Senba Hiroshi, Suzuki Mariko, Mizuguchi Yuki, Izumi Yoko, Sato Suguru, Nakabayashi Akira, Tanaka Mamoru
発行年月	2015
概要	This is a retrospective study aimingto clarify the current status of preimplantation genetic diagnosis (PGD) in Japan. Our data were collected from 12 facilities between September 2004 and September 2012, and entered into a database. A majority of PGD in Japan was performed for balanced structural chromosomal abnormalities in couples with recurrent miscarriage. PGD for monogenic diseases was performed only in two facilities. The average maternal age was 38 years for monogenic diseases and 40 years for chromosomal abnormalities. Overall there have been671 cycles to oocyte retrieval reported. Of these cycles, 85% (572 cycles)were for chromosomal abnormalities, and 15% (99 cycles) for monogenic diseases. Diagnosis rates in the current study were 70.8% for monogenic diseases and 94.0% for chromosomal abnormalities. Rates of embryo transfer of PGD were 62.7% for monogenic diseases and 25.5% for chromosomal abnormalities. Clinical pregnancy rates per embryo transfer were 12.0% for monogenic diseases and 35.6% for chromosomal abnormalities. Our study is the first PGD report from all facilities which had the approval of the ethics committee of the Japanese Society of Obstetrics and Gynecology. We have built a basis for gathering continuous PGD data in Japan.
DOI	10.6026/97320630011254
PMID	26124570